In vivo-induced genes in Pseudomonas aeruginosa.

نویسندگان

  • M Handfield
  • D E Lehoux
  • F Sanschagrin
  • M J Mahan
  • D E Woods
  • R C Levesque
چکیده

In vivo expression technology was used for testing Pseudomonas aeruginosa in the rat lung model of chronic infection and in a mouse model of systemic infection. Three of the eight ivi proteins found showed sequence identity to known virulence factors involved in iron acquisition via an open reading frame (called pvdI) implicated in pyoverdine biosynthesis, membrane biogenesis (FtsY), and adhesion (Hag2).

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Antibiotic resistance profiles of Pseudomonas aeruginosa isolates containing virulence genes

Background: A most common opportunistic pathogen, Pseudomonas aeruginosa is present in both humans and animals and responsible for various nosocomial infections and healthcare settings related infections. Different virulence genes like; oprL (membrane lipoprotein L) and toxA (exotoxin A i.e. ETA) in P. aeruginosa, assist in its pathogenicity, toxicity and contribute to high antibiotic resistanc...

متن کامل

Frequency of Exotoxin A, Exoenzyme, Alginate and PprI and PprL Virulence Genes in Animal and Human Pseudomonas Aeruginosa Isolates and Determination of Antibiotic Resistance Pattern

Background and Aims: Pseudomonas aeruginosa is the most important cause of various nosocomial infections and mastitis in dairy cattle and the development of antibiotic resistance. The aim of this study was to determine the antibiotic resistance of Pseudomonas aeruginosa and the presence of virulence genes in human and animal samples. Materials and Methods: In this study, 102 human and animal st...

متن کامل

Multidrug-Resistant Virulence Genes in Isolates of Pseudomonas aeruginosa in Iranian Clinical Samples: A Review-Meta-Analysis

 Background and purpose: Pseudomonas infections include urinary tract infections (UTIs), respiratory infections, soft tissue infections, dermatitis, bacteremia, gastrointestinal, bone and joint infections, and systemic types of infections, especially in hospitalized patients with severe burns, or patients with immunosuppression such as cancer or AIDS. Considering the importance of the virulence...

متن کامل

Molecular Study of PER and VEB Genes is Multidrug Resistant Pseudomonas aeroginosa Isolated From Clinical Specimens in Isfahan/Iran and their Antibiotic Resistance Patterns

Background & Aims: Duo to clinical use of antibiotics, pseudomonas aeruginosa strains with multiple drugs resistance have significantly increased throughout the world. Betalactamase production is one of the Mechanisms involved in resistance to pseudomonas aeruginosa resulting in many problems in the treatment of infections caused by this bacterium. The aim of this study was molecular analysis o...

متن کامل

Utility of In Vivo Transcription Profiling for Identifying Pseudomonas aeruginosa Genes Needed for Gastrointestinal Colonization and Dissemination

Microarray analysis of Pseudomonas aeruginosa mRNA transcripts expressed in vivo during animal infection has not been previously used to investigate potential virulence factors needed in this setting. We compared mRNA expression in bacterial cells recovered from the gastrointestinal (GI) tracts of P. aeruginosa-colonized mice to that of P. aeruginosa in the drinking water used to colonize the m...

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Infection and immunity

دوره 68 4  شماره 

صفحات  -

تاریخ انتشار 2000